"Alzheimer's Afternoons" Online Seminar Series

Every Tuesday & Thursday @ 3:00 PM (EDT) Link to join zoom: bit.ly/3bTrtNc Or, copy and paste:

password: AD https://us04web.zoom.us/j/704579135?pwd=WUd0dkgyUTl6ZE1LUkU1SUs3d1FoQT09

* presentations will be recorded and posted online for 24-48 hr to accommodate other time zones (unless requested otherwise by the speaker)

#ERROR!

Date Speaker Talk Title Speaker affiliation Speaker email Lab Website Twitter Handle Key References; Additional Info

Thur 3/26/20 Lance Johnson Tipping the energy balance: APOE, AD and cerebral metabolism University of Kentucky [email protected] www.LJohnsonLab.com @LJohnsonLab https://www.ncbi.nlm.nih.gov/pubmed/31931141 https://www.ncbi.nlm.nih.gov/pubmed/30791549

Tues 3/31/20 Gareth Howell MODEL-AD: Towards the next generation of mouse models for Alzheimer's disease The Jackson Laboratory [email protected] model-ad.org @model_ad_alz https://www.model-ad.org/2019/06/27/model-ad-presentations-at-aaic-2019 https://www.ncbi.nlm.nih.gov/pubmed/31929156 https://www.ncbi.nlm.nih.gov/pubmed/31878951

Thur 4/2/20 Rik van der Kant Cholesterol metabolism as a dual driver of neuronal AD pathology Vrije Universiteit Amsterdam [email protected] @rikvanderkant https://www.ncbi.nlm.nih.gov/pubmed/30686764

Tues 4/7/20 Heather Ferris Astrocyte cholesterol is essential for amyloid beta production University of Virginia [email protected] @DrHeatherFerris https://www.ncbi.nlm.nih.gov/pubmed/28096339

Thur 4/9/20 Tal Nuriel Utilizing Systems Biology Approaches to Uncover Novel Effects of APOE4 Expression in an AD-vulnerable Brain Region Columbia University [email protected] tal https://www.ncbi.nlm.nih.gov/pubmed/32152337 https://www.ncbi.nlm.nih.gov/pubmed/29311783 https://www.ncbi.nlm.nih.gov/pubmed/29133888

Tues 4/14/20 Misha Zilberter Brain glucose hypometabolism and network hyperexcitability in Alzheimer's disease Gladstone Institutes [email protected] @MZilberter https://www.ncbi.nlm.nih.gov/pubmed/28463438

Thur 4/16/20 Julia TCW Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia Icahn School of Medicine at Mount Sinai [email protected] https://www.biorxiv.org/content/10.1101/713362v1

Tues 4/21/20 Connie Cortes Enhance Skeletal Muscle Proteostasis as a Novel Determinant of Aging and Alzheimer's Disease University of Alabama at Birmingham [email protected] https://sites.uab.edu/cjcortes/ @constanza343 https://www.ncbi.nlm.nih.gov/pubmed/29852219

Thur 4/23/20 Heather Wilkins Amyloid Precursor Protein and Bioenergetics University of Kansas Medical Center [email protected] @DrHeaterW https://www.ncbi.nlm.nih.gov/pubmed/28491064 https://www.ncbi.nlm.nih.gov/pubmed/28598847

Tues 4/28/20 Shannon Macauley Targeting vascular KATP channel activity in Alzheimer's disease Wake Forest School of Medicine [email protected] www.macauleylab.com @macauleylab https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497756 https://www.ncbi.nlm.nih.gov/pubmed/31555072

Thur 4/30/20 Kristen Zuloaga Sex Differences in Metabolic and Vascular Contributions to Dementia Albany Medical Center [email protected] zuloagalab.com @Zuloaga_Lab https://www.ncbi.nlm.nih.gov/pubmed/31871124 https://www.ncbi.nlm.nih.gov/pubmed/30580011 https://www.ncbi.nlm.nih.gov/pubmed/30471324

Tues 5/5/20 Donna Wilcock Leveraging mouse and human studies to understand mechanisms of VCID University of Kentucky [email protected] @wilcocklab https://www.ncbi.nlm.nih.gov/pubmed/32116527 https://www.ncbi.nlm.nih.gov/pubmed/31888650 https://www.ncbi.nlm.nih.gov/pubmed/31362539

Thur 5/7/20 Qi Zhang Membrane Cholesterol Homeostasis and APP Trafficking - A Hidden Link Between Familial And Sporadic AD FAU Brain Institute [email protected]

Tues 5/12/20 Axel Montagne APOE4-associated vascular dysfunctions in both humans and animal models University of Southern California [email protected] @AxL_Montagne https://www.nature.com/articles/s41586-020-2247-3

Thur 5/14/20 Liz Head Alzheimer disease in Down syndrome: Link between Cerebrovascular pathology and neuroinflammation UC Irvine [email protected] @ElzHead https://www.ncbi.nlm.nih.gov/pubmed/30733618

Tues 5/19/20 Jill Morris Systemic metabolism, aging, and Alzheimer’s Disease University of Kansas Medical Center [email protected] @morrisjillk https://www.ncbi.nlm.nih.gov/pubmed/31491971 https://www.ncbi.nlm.nih.gov/pubmed/29351484 https://www.ncbi.nlm.nih.gov/pubmed/28550261 https://www.ncbi.nlm.nih.gov/pubmed/28187125

Thur 5/21/20 Josh Morganti Aging and brain injury: a recipe for degenerative astrocyte:microglia signaling University of Kentucky [email protected] @Morganti_Lab

Tues 5/26/20 Michelle James PET imaging of neuroinflammation in AD Stanford University [email protected] http://med.stanford.edu/jameslab.html @mjameslab

Thur 5/28/20 Soyon Hong More than Bystanders in Dementia: Learning What Microglia Do University College London [email protected] https://www.ucl.ac.uk/biosciences/departments/neuroscience-physiology-pharmacology/neuroscience-phd/supervisors/neuroscience-soyon @soyonhonglab

Tues 6/2/20 Gil Di Paolo Control of microglial cholesterol metabolism by TREM2 and APOE Denali Therapeutics [email protected] https://pubmed.ncbi.nlm.nih.gov/31902528/

Thur 6/4/20 Henne Holstege How did cognitively healthy centenarians preserve their cognitive health? Findings from the 100-plus Study Amsterdam UMC [email protected] www.100plus.nl @HolstegeHenne https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290855/

Tues 6/9/20 Melissa Murray Paradoxical Aging in Young Onset Alzheimer’s disease Mayo Clinic Florida [email protected] https://www.mayo.edu/research/labs/translational-neuropathology/overview @DrNeuroChic https://pubmed.ncbi.nlm.nih.gov/31175025/

Thur 6/11/20 Malu Tansey Targeting soluble TNF to reduce metabolic and immune dysfunction and AD risk University of Florida [email protected] @malutansey https://pubmed.ncbi.nlm.nih.gov/31892368

Tues 6/16/20 Na Zhao Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways in multi-omics profiling Mayo Clinic Florida [email protected] @NaaZhao https://www.cell.com/neuron/pdfExtended/S0896-6273(20)30185-9

Thur 6/18/20 Amira Latif Hernandez Small molecule neurotrophin receptor ligands to treat Alzheimer's disease Stanford University [email protected] https://med.stanford.edu/longo-lab.html

Tues 6/23/20 Oliver Bracko The Contribution of Capillary Stalling to Brain Blood Flow Reductions in Alzheimer’s Disease Cornell University [email protected] @obracko

Thur 6/25/20 Virginie Buggia-Prevot Neurotoxicity of Cancer Treatments: Similarities with AD and Translational Potential The Neurodegeneration Consortium-MD Anderson Cancer Center [email protected] http://www.neurodegeneration-consortium.org/ @vbprevot

Tues 6/30/20 Mychael Lourenco Molecular mechanisms of physical exercise-induced neuroprotection in Alzheimer's models Fed University of Rio de Janeiro, Brazil [email protected] www.lourencolab.org @mvlourenco

Thur 7/2/20 Catherine Kaczorowski Single nuclear RNA sequencing reveals microglia diversity associated with cognitive resilience in the AD-BXD mouse model of human Alzheimer’s disease The Jackson Laboratory [email protected] https://www.jax.org/research-and-faculty/research-labs/the-kaczorowski-lab @KaczorowskiLab

Tues 7/7/20 Niccolo Terrando Neuroimmune Interactions in Delirium Superimposed on Dementia Duke University [email protected] https://anesthesiology.duke.edu/?page_id=838077 @niccoloterrando

Thur 7/9/20 Orly Lazarov Hippocampal neurogenesis in Alzheimer's disease The University of Illinois at Chicago

Tues 7/14/20 Ashley Walker Vascular aging and Alzheimer’s disease: Role of Large artery stiffness University of Oregon [email protected] https://vascularlab.uoregon.edu/ @Ashley_E_Walker

Thur 7/16/20 Hussein Yassine Mechanisms of Neuroinflammation and APOE4 University of Southern California [email protected] www.yassinelab.com

Tues 7/21/20 Jessica Wu Physiological models of tau seeding and propagation for tau-related drug discovery AbbVie [email protected]

Thur 7/23/20 Abid Hussaini Impact of Amyloid beta and Tau Pathology on Neuronal Function Columbia University Irving Medical Center [email protected] hussainilab.org @hussainilab

Tues 7/28/20 Alzheimer's Association International Conference [Virtual Event]. https://www.alz.org/aaic/overview.asp

Thurs 7/30/20

Organizer initated PAUSE in sign ups past 8/3/20 (we will reassess in a month or so). You all are fantastic! Thanks for the support!